ClinGen is a National Institutes of Health (NIH)-funded resource dedicated to determining which genetic variants are most relevant to patient care by harnessing both research data and the data from the hundreds of thousands of clinical genetics tests being performed each year, as well as supporting expert curation of these data. In 2013, the National Human Genome Research Institute (NHGRI), along with the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Cancer Institute (NCI), awarded over $25 million to support a consortium of research groups to design and implement a framework for evaluating which variants play a role in disease and those that are relevant to patient care. The groups will work closely with the National Center for Biotechnology Information (NCBI) of the National Library of Medicine (NLM), which will distribute this information through its ClinVar database. Learn about each of the groups involved in the ClinGen Resource, their individual charges and their collaborative efforts.
Several key goals to support our overall mission of raising the quality of patient care include:
ClinGen is primarily funded by the National Human Genome Research Institute (NHGRI), through the following three grants:
ClinGen receives support from the National Cancer Institute (NCI) through the following contract:
ClinGen also receives funding through the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
ClinVar is supported by the Intramural Research Program of the NIH, National Library of Medicine.