Real-time unfettered access to data from disparate sources, including an electronic health record (EHR) system, accelerates translational research and provides the foundation for comparative effectiveness studies. Geisinger Health System has created a comprehensive enterprise-level data warehouse. The warehouse receives feeds from multiple-source systems, including our EHR, financial decision support, claims and patient satisfaction. The source data are transformed through a standard "Extract-Transform-Load" process. Expansion to additional data-source systems (e.g., niche specialty systems such as oncology) is being accomplished in stages and will eventually encompass all high-value data sources. Clinical Decision Intelligence System (CDIS) is transforming opportunities for comparative effectiveness research. A de-identified research version of CDIS is accelerating the means by which data can be used to advance knowledge.