Research is conducted across the Geisinger Health System both in its dedicated research centers and institutes, as well as in its clinical departments and service lines. Research centers and cross-disciplinary institutes are home to most of Geisinger's full time researchers as well as the core facilities that support the research enterprise.
- The Sigfried and Janet Weis Center for Research,focuses on laboratory-based research on the molecular and cellular basis of diseases and on translational research, and in particular genomic medicine.
- The Geisinger Center for Health Research advances outcomes and population-based research and devises new models of care to improve the efficiency and quality of care to patients.
- The Center for Re-engineering Health Care seeks to improve healthcare delivery by applying the principles of engineering to health care. The CRH is one of three centers under the Institute for Advanced Applications. The other two centers are the Center for Emerging Technology and Informatics and Center for Clinical Innovation
- The Geisinger Obesity Institute facilitates research that addresses the challenges of obesity and obesity-related disease
- The Genomic Medicine Institute uses genomic medicine to develop innovative treatment strategies and cures
- The Autism and Developmental Medicine Institute (ADMI) is dedicated to clinical care, research, and education that will improve and expedite the diagnosis, treatment, and care of children with autism spectrum disorders and other developmental disorders
- The Environmental Health Institute works to understand links between land use, ecosystem health, community health, and human health, and to translate knowledge into changes that promote sustainable healthy communities.
Extensive research on specific diseases and conditions is conducted in Geisinger's clinical departments and clinical service lines, often in partnership with colleagues in the Centers and Institutes. Research in Cardiology and Vascular Surgery is organized under the umbrella of the Cardiovascular Center for Clinical Research, which provides resources and support for a wide range of clinical trials and outcomes research. Rheumatology, Nephrology, Orthopaedics and Neurosurgery, among others have developed research programs that include health services, outcomes, and laboratory based approaches. Both pediatric and adult oncology departments are actively involved in trials through the National Cancer Institute-designated cooperative oncology groups, an effort which is directly facilitated by Geisinger's Community Clinical Oncology Program (CCOP) award from the National Institutes of Health.
In addition to many project-specific collaborations, Geisinger has created a number of formal, External Affiliations, which serve to enrich its intellectual and scientific environment, provide access to students and research resources, and extend the reach of Geisinger's efforts. External affiliations, which involve many research networks, include but are not limited to:
- Geisinger's membership with the HMO Research Network, a consortium that fosters and supports population-based research collaboration,
- Research affiliations with Johns Hopkins University through the Environmental Health Institute as well as a project funded by a grant from NIH with the Johns Hopkins Global Center on Childhood Obesity.
- The eMERGE network, a national consortium exploring the feasibility of using electronic health records systems to investigate gene-disease relationships.
- Bucknell University, a national liberal arts institution located 15 miles from the main campus of Geisinger. The Bucknell Geisinger Research Initiative encourages increased research and educational linkages between Geisinger and Bucknell and includes a program of seed grants for collaborative projects between the two institutions.