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Resolution of Co-morbidities


comorbiditiesMorbid obesity is often associated with many different co-morbidities such as type 2 diabetes, hypertension, cardiovascular disease, stroke, sleep apnea, and gallbladder disease. Research has shown that many of these co-morbidities can be reduced through bariatric surgery. For example, evidence suggests that the rearrangement of the intestines during bariatric surgery and the change in physiological mechanisms can possibly result in remission of type 2 diabetes within days of surgery. Our research aims to better understand these mechanisms to help better predict post-surgery outcomes.

Investigators interested in topic


Gerhard, GS., Styer, AM., Wood, GC., Roesch, SL., Petrick, AT., Gabrielsen, J., Strodel, WE., Still, CD., Argyropoulos, G.: A role for fibroblast growth factor 19 and bile acids in diabetes remission after Roux-en-Y gastric bypass. Diabetes Care July 2013; 36(7):1859-1864

Gorden, A., Yang, R., Yerges-Armstrong, LM., Ryan, LM., Speliotes, E., Borecki, IB., Harris, TB., Chu, X., Wood, GC., Still, CD., Shuldiner, AR., Gerhard, GC.: Genetic Variation at NCAN Locus Is Associated with Inflammation and Fibrosis in Non-Alcoholic Fatty Liver Disease in Morbid Obesity. Human Heredity 2013; 75(1): 34-43.

Kumashiro, N., Erion, D., Zhang, D., Kahn, M., Beddow, S., Chu, X., Still, C., Gerhard, G., Han, X., Dziura, J., Petersen, K., Samuel, V., Shulman, G.: Cellular Mechanism of Insulin Resistance in Nonalcoholic Fatty Liver Disease. Proceedings of the National Academy of Sciences (PNAS) 2011; 108(39): 16381-16385.