Information technology is widely viewed as a critical component for delivering high quality care. Geisinger Health System (GHS) has had an electronic health record (EHR) in place for more than a decade. Researchers leverage GHS’s depth of experience with the EHR and other sources of digitized health information. When combined with proximity to more than 40 outpatient clinics, investigators have access to a unique and compelling environment for research at the intersection of informatics and health services. Our goal is to develop software, tools, processes, and care delivery models that empower patients to take an active role in managing their health. By building strong relationships with our primary care providers, we can test these tools and care delivery models in one or more care settings using a variety of study designs (including RCTs across multiple clinics). We place a strong emphasis on developing solutions that create value, are business-sensible, and lead to meaningful improvement in outcomes from both the patient and provider perspective.