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Research Programs

Molecular Neuroscience
Cardiovascular
Obesity, Metabolic Disease and Inflammatory Disease
Cancer
Genomics

 

rothblum research programsMolecular Neuroscience

Cardiovascular

  • Gerda Breitwieser - calcium sensing receptor in cardiovascular disease
  • David Carey - pathophysiology of abdominal aortic aneurysm
  • Helen Kuivaniemi - genetics and genomics of abdominal aortic aneurysm
  • Tooraj Mirshahi - animal models; heart failure; role of ion channels in cardiac function and disease
  • Anne Moon - pathobiology of cardiac development; arrhythmia syndromes
  • Janet Robishaw - animal models; heart failure; congenital heart problems; pathological angiogenesis
  • Gerard Tromp - genetics of abdominal aortic aneurysm

Obesity, Metabolic Disease and Inflammatory Disease

  • George Argyropoulos - obesity and diabetes; human and mouse models; regulation of appetite
  • Catherine Berlot - G-protein modulation of T cell signaling 
  • Gerda Breitwieser - intestinal stem cells; peripheral regulation of obesity
  • David Carey - extracellular matrix signaling in obesity
  • Tooraj Mirshahi - leptin-meanocortin pathway; mechanism of weight loss, neuroendocrine control of metabolism, remission of T2D
  • Anne Moon - role of Tbx3 in metabolism
  • Janet Robishaw - animal models; resistance to hight fat diet induced obesity; adipose derived stem cells

Cancer

Genomics

  • George Argyropoulos - Genomics of obesity and diabetes
  • Gerda Breitwieser - transcriptomics of vascular disease and obesity
  • David Carey - incorporating genomic information into clinical practice; identification of genetic risk factors for AAA
  • Helen Kuivaniemi - genomics of abdominal aortic aneurysms
  • Tooraj Mirshahi - human variants associated with disease
  • Anne Moon - identifying candidate genes for human cardiac malformations; applied pharmacogenomics
  • Janet Robishaw - association of human genetic variants with clinical phenotypes
  • Gerard Tromp - Bioinformatics and computational biology; electronic phenotyping using EMR data; genome-wide association; next-generation sequence analysis
  • Wannian Yang - Genomic alterations and tumor genesis and progression