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Urology Research

Clinical Trials

LIFT Pivotal Study – Luminal Improvement Following Prostatic Tissue Approximation for the Treatment of Lower Urinary Tract Symptoms

The Prostatic Urethral Lift procedure, a new, tissue-sparing minimally invasive treatment for BPH, is based on the hypothesis that LUTS secondary to BPH could be treated by mechanically disassociating the obstructing prostatic lobes instead of removing or injuring prostate tissue, thereby offering the potential to relieve symptoms with low morbidity and a better subject experience.

Enrollment in this trial is closed.

ADAPT- An International Phase 3 Randomized Trial of Autologous Dendritic Cell Immunotherapy (AGS-003) Plus Standard Treatment of Advanced Renal Cell Carcinoma

This study will investigate the combination of an autologous ribonucleic acid (RNA) electroporated dendritic cell (DC) based immunotherapy, AGS-003, plus standard treatment. The primary objective in this study is to determine the median overall survival achieved by this combination compared to the use of standard treatment, in a population of adults with advanced renal cell carcinoma (RCC), with nephrectomy indicated, and with remaining measurable metastatic disease.

Enrollment in this trial is not yet open.

Protocol OG09002- A Multi-Center, Double-Blind, Placebo-Controlled, Dose-Titration Study Evaluating the Efficacy, Safety, Pharmacodynamics of Oxybutynin Chloride Topical Gel for the Treatment of Detrusor Overactivity Associated with a Neurological Condition in Pediatric Subjects

This study will be a multi-center, double-blind, placebo-controlled, dose-titration study in pediatric subjects, 6 years-of-age to 16 years-of-age and 11 months inclusive, with Detrusor overactivity associated with a neurological condition. Subjects must be a suitable candidate for anticholinergic therapy and must be using clean intermittent catheterization (CIC) for bladder control. The primary objective is to evaluate the efficacy and daily treatment of OTG in pediatric subjects during the first 6 weeks of a 14-week treatment period.

Enrollment in this trial is not yet open

Studies

Study# 2009-0146: Operative Technique for Parallel Extravesical Reimplantation in Laparoscopic Robotic-Assisted Urinary Reconstruction

This study aims to describe the operative technique for parallel extravesical reimplantation in laparoscopic robotic-assisted lower urinary tract reconstruction, and present our technique for creation of an anti-refluxing continence mechanism during this procedure.

There is no enrollment for this retrospective review.

Study#2005-0272: Trans-Rectal Ultrasound Guided Prostate Needle Biopsy Database 

This study creates a database of all men who have prostate biopsy at GMC to examine relationships between number of biopsies, prostate volume, PSA velocity, and prostate surgeries over time.  

There is no enrollment for this retrospective review.

Study#2009-0276: Monitoring of Hypospadias Repair Outcomes Using Cumulative Summation Charts 

Hypospadias repair is associated with a number of major and minor complications including bleeding, meatal stenosis, urethrocutaneous fistula, urethral diverticulum, urethral stricture, and persistent penile curvature.  When considering the technically challenging nature and the various options for repair, the need to formally monitor surgical outcomes is of great importance. 

There is no enrollment for this retrospective review.

Study#2008-0234: Retrospective Analysis of Robotic-Assisted Laparoscopic Radical Nephrectomy and Partial Nephrectomy

The aim of this study is to review all Robotic-Assisted Laparoscopic Radical Nephrectomy and Partial Nephrectomy cases and generate data regarding patient parameters, perioperative variables, and postoperative outcomes, ie: age, sex, co-morbidities, operative times, hospital stay, pain control, and complications. This surgery is also performed using either pure laparoscopic approach, hand assisted laparoscopic approach, or open approach. This information would be useful to the growing literature on robotic surgery in general.

There is no enrollment for this retrospective review.

Study#2005-0297: Retrospective analysis of the safety and efficacy of percutaneous renal cryoablation 

This is an analysis of clinically relevant information of  patients who have undergone percutaneous renal cryoablation to treat renal tumors. The purpose of the study is to evaluate safety (adverse events) and present data reflecting short term oncologic efficacy of renal cryoablation (using extremely cold temperatures to ablate tissue/tumors).

There is no enrollment in this retrospective review.

Study# 2008-0253: Retrospective Analysis of Transperineal and Transrectal Prostate Biopsy Data 

The aim of this study is to review both transrectal prostate biopsy and transperineal prostate biopsy data, which has been prospectively collected, and to generate data regarding patient parameters, perioperative variables, and postoperative outcomes, i.e.: age, co-morbidities, operative times, hospital stay, pain control, and complications. 

There is no enrollment for this retrospective review.