FH is the most common genetic cause of early, life-threatening cardiovascular disease
DANVILLE, Pa. – Researchers at Geisinger have received $2.8 million from the National Heart, Lung, and Blood Institute of the National Institutes of Health to improve detection of and family screening for familial hypercholesterolemia (FH). The project will be executed in collaboration with the FH Foundation, a patient-centered nonprofit organization dedicated to research, advocacy and education about FH.
People with FH have very high LDL cholesterol levels, and FH is the most common genetic cause of early, life-threatening cardiovascular disease. FH causes 20 percent of early heart attacks (before age 45). Significant reduction of LDL cholesterol beginning in childhood is key to successful risk reduction.
The disorder affects more than 34 million people worldwide and more than 1.3 million people in the United States, but less than 10 percent of these are diagnosed. Family screening, known as cascade screening, has been shown to improve diagnosis rates, but an effective method for this screening has not been successfully implemented in the U.S.
“Familial hypercholesterolemia is profoundly underdiagnosed in the U.S., leading to premature death in the absence of proper identification and subsequent treatment,” said Amy Sturm, MS, professor at Geisinger’s Genomic Medicine Institute and co-director of the MyCode Genomic Screening and Counseling Program, and one of the study’s principal investigators. “This study will focus on not only identifying FH, but also the development and design of innovative tools and programs to help individuals with FH encourage their at-risk family members to be screened for the disorder.”
The study, “Identification Methods, Patient Activation, and Cascade Testing for FH” (IMPACT-FH), aims to optimize FH identification methods, increase screening of at-risk relatives of individuals with FH, and determine how to implement needed changes in healthcare systems across the U.S. The study will also assist individuals with FH in communicating their diagnosis and genomic risk results to at-risk relatives to motivate them to undergo screening. Sam Gidding, M.D., of the FH Foundation is the other principal investigator on the study.
“You never find an individual with FH, you always find a family,” said Katherine Wilemon, founder and chief executive officer of the FH Foundation. “This study will help evaluate the best methods that individuals with FH can use to communicate their diagnosis results with their at-risk family members in order to motivate those family members to undergo family screening.”
FH is one of more than 30 conditions screened for in MyCode, Geisinger’s groundbreaking genomic medicine project. Since 2007, more than 250,000 people have enrolled in the study and nearly 1,500 have received clinically actionable results. These results allow patients to work with their care providers to prevent or detect disease in its early stages, leading to better health outcomes.
About the FH Foundation
The FH Foundation is a leading research and advocacy non-profit organization focused on reducing heart disease by driving scientific understanding and evidence-based care of familial hypercholesterolemia. Our mission is to save lives by contributing to scientific research that leads to greater understanding and improved diagnosis and treatment of FH worldwide. Learn more at thefhfoundation.org or connect with us on Facebook, Instagram, LinkedIn and Twitter.
Geisinger is committed to making better health easier for the more than 1 million people it serves. Founded more than 100 years ago by Abigail Geisinger, the system now includes 10 hospital campuses, a health plan with more than half a million members, a Research Institute and the Geisinger Commonwealth School of Medicine. With nearly 24,000 employees and more than 1,700 employed physicians, Geisinger boosts its hometown economies in Pennsylvania by billions of dollars annually. Learn more at Facebook, Instagram, LinkedIn and Twitter.
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