COVID-positive people have more severe strokes, Geisinger-led study finds

DANVILLE, Pa. – Among people who have strokes and COVID-19, there is a higher incidence of severe stroke as well as stroke in younger people, according to new data from a multinational study group on COVID-19 and stroke, led by a team of Geisinger researchers. 

The COVID-19 Stroke Study Group’s latest report, published in the journal Stroke, focused on a group of 432 patients from 17 countries diagnosed with COVID-19 and stroke. Among this group, the study found a significantly higher incidence of large vessel occlusion (LVO) — strokes caused by a blockage in one of the brain’s major arteries that are typically associated with more severe symptoms. Nearly 45% of strokes in the study group were LVOs; in the general population, 24 to 38% of ischemic strokes are LVOs. 

The study group also had a high percentage of young patients who had strokes: more than a third were younger than 55, and nearly half were younger than 65. Pre-pandemic general population data showed 13% of strokes occurred in people under 55, and 21% in people younger than 65. 

The data showed that that less-severe strokes, mostly in critically ill patients or overwhelmed health centers, were underdiagnosed. This finding is significant, the research team said, as minor or less-severe stroke may be an important risk factor for a more severe stroke in the future.

“Our observation of a higher median stroke severity in countries with lower healthcare spending may reflect a lower capacity for the diagnosis of mild stroke in patients during the pandemic, but this may also indicate that patients with mild stroke symptoms refused to present to the hospitals,” said Ramin Zand, M.D., a vascular neurologist and clinician-scientist at Geisinger and leader of the study group.

Throughout the pandemic, people with COVID-19 have reported symptoms involving the nervous system, ranging from a loss of smell or taste to more severe and life-threatening conditions such as altered mental state, meningitis and stroke. A group of Geisinger scientists and a team of experts from around the world formed the COVID-19 Stroke Study Group shortly after the pandemic began to study the correlation between COVID-19 infection and stroke risk.

Results from the first phase of the study, which included data on 26,175 patients, indicated an overall stroke risk of 0.5% to 1.2% among hospitalized patients with COVID-19 infection. The finding demonstrated that, even though there were increasing reports of patients with COVID-19 experiencing stroke, the overall risk is low. 

“Our initial data showed that the overall incidence of stroke was low among patients with COVID-19, and while that hasn’t changed, this new data shows that there are certain groups of patients — for example, younger patients — who are more affected,” said Vida Abedi, Ph.D., a scientist in the department of molecular and functional genomics at Geisinger. “We hope these findings highlight new research directions to better identify patients at risk and help improve the quality of care.”

Geisinger has an exciting research environment with more than 50 full-time research faculty and more than 30 clinician scientists. Areas of expertise include precision health, genomics, informatics, data science, implementation science, outcomes research, health services research, bioethics and clinical trials.

About Geisinger
Geisinger is among the nation’s leading providers of value-based care, serving 1.2 million people in urban and rural communities across Pennsylvania. Founded in 1915 by philanthropist Abigail Geisinger, the non-profit system generates $10 billion in annual revenues across 134 care sites - including 10 hospital campuses, and Geisinger Health Plan, with 600,000 members in commercial and government plans. The Geisinger College of Health Sciences educates more than 5,000 medical professionals annually and conducts more than 1,400 clinical research studies. With 26,000 employees, including 1,600 employed physicians, Geisinger is among Pennsylvania’s largest employers with an estimated economic impact of $14 billion to the state’s economy. On March 31, 2024, Geisinger became the first member of Risant Health, a new nonprofit charitable organization created to expand and accelerate value-based care across the country.  Learn more at geisinger.org or connect with us on Facebook, Instagram, LinkedIn and X.