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MBP 88.0 Halaven (eribulin mesylate)
Halaven (eribulin) is a nontaxane microtubule dynamics inhibitor that inhibits the growth phase of microtubules without affecting the shortening phase, and sequesters tubulin into nonproductive aggregates. Eribulin exerts its effects via a tubulin-based antimitotic mechanism leading to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage
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