Medical benefit pharmaceutical policies for providers
See the latest updates to our medical benefit pharmaceutical policies.
MBP 101.0 Zaltrap (ziv-aflibercept)
Zaltrap (ziv-aflibercept) acts as a soluble receptor that binds to human VEGF-A, to human VEGF-B), and to human PlGF. By binding to these endogenous ligands, ziv-aflibercept can inhibit the binding and activation of their cognate receptors. This inhibition can result in decreased neovascularization and decreased vascular permeability.
MBP 15.0 Zevalin (Ibritumomab tiuxetan (IDEC Y2B8))
ZevalinTM (ibritumomab tiuxetan) is the immunoconjugate resulting from a stable thiourea covalent bond between the monoclonal antibody ibritumomab and the linker-chelator tiuxetan. Zevalin binds specifically to the CD20 antigen (human B-lymphocyte-restricted differentiation antigen, Bp35) and prevents shedding from the cell surface and internalization upon antibody binding.
MBP 153.0 Zinplava (bezlotoxumab)
Zinplava (bezlotoxumab) is a human IgG1 monoclonal antibody that binds to C. difficile toxin B and neutralizes it to prevent its toxic effects; bezlotoxumab does not bind to C. difficile toxin A.
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