Medical benefit pharmaceutical policies for providers
See the latest updates to our medical benefit pharmaceutical policies.
MBP 89.0 Xgeva (denosumab)
Xgeva (denosumab) binds to RANKL, a transmembrane or soluble protein essential for the formation, function, and survival of osteoclasts, the cells responsible for bone resorption. Xgeva prevents RANKL from activating its receptor, RANK, on the surface of osteoclasts and their precursors. Increased osteoclast activity, stimulated by RANKL, is a mediator of bone pathology in solid tumors with osseous metastases.
MBP 80.0 Xiaflex (collagenase clostridium histolyticum)
Xiaflex (collagenase clostridium histolyticum) is a combination of bacterial collagenases isolated and purified from the fermentation of C. histolyticum bacteria; collagenase lyses collagen, leading to enzymatic disruption of contracted Dupuytren cord or Peyronie plaque (both comprised primarily of collagen).
MBP 110.0 Xofigo (radium Ra 223 dichloride)
Xofigo (radium Ra 223 dichloride) is an alpha particle-emitting radioactive therapeutic agent indicated for the treatment of patients with castration-resistant prostate cancer, symptomatic bone metastases and no known visceral metastatic disease
MBP 22.0 Xolair (Omalizumab)
Xolair (Omalizumab) is a recombinant humanized monoclonal antibody to immunoglobulin E (IgE). Currently, Xolair is available as a subcutaneous injection only.
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